Physician and the Paradigm Shift In Medicine

TOPIC: 

PHYSICIAN AND THE PARADIGM SHIFT IN MEDICINE

SPEAKER:
Dr. KP Aravindan
(M.B.B.S., M.D., Pathology)
Emeritus Scientist
Former Professor and Head of the Dept of Pathology
Medical College, Kozhikode, Kerala

OVERALL LEARNING OBJECTIVE:

• Discuss paradigm shift of chromosome studies in human leukemia specialized on chronic granulocytic leukemia.
• Discuss new methods and recent technology to sequencing DNA and RNA that revolutionize the study of genomics, molecular biology, and bioinformatics.
• Understand about Chronic.Myelogenous Leukemia (CML), which is usually marked by a chromosome change such as Philadelphia chromosome and determine fused transcript of ABL and BCR genes in Chronic Myelogenous Leukemia (CML).
• Discovery of the mechanism of imatinib resistance due to up-regulating tumor suppressor.
• Understand the chromosome studies revealing genome-wide mRNA and micro RNA expression pattern in leukemic cells as a tumor suppressor for regaining of chemotherapeutic imatinib response.
• Summarize Phenotypes and Genotypes.
• Discuss differentiation of Genetics Vs Genomics.
• Explore NGS (Next Generation Sequencing) which is used to describe a number of different modern sequencing technologies.
• Describe strategies, steps, and economics of genome sequencing and software use.
• Describe different NGS (Next Generation Sequencing) applications on Germline mutations, Somatic mutations, and Genomes of pathogens.
• Case studies on NGS technologies and NGS applications like whole Genome sequencing (WGS), whole Exome sequencing(WES), and sequencing of limited panels (selected amplicons)
• Describe and demonstrate Merkel Cell cancer, geographically.